DMRT1 inhibition?
A long time ago I read this story -- http://blogs.discovermagazine.com/notrocketscience/2011/07/20/one-gene-keeps-mickey-from-turning-into-minnie/#.WRXzMca1uMo -- and was kind of curious about whether there were ways to inhibit DMRT1 expression for an adult human, say, myself >_>. Its more hypothetical than practical, since I don't even know where to start suppressing a gene or its activity in an adult human, but - IF there were a way to do something like that it seems like it could save me (and other trans folk) a lot of time and trouble (or make me really sick and have terrible health complications in some way... hopefully not). Obviously if it worked well I wouldn't be fertile or anything, but it could mean an end to taking hormone pills my whole life...
It looks like in mice this was achieved using, well, tamoxifen inducible cre transgenic mice + tamoxifen, but I really don't understand cre/lox recombination.. found a wiki on it here that gives me a few clues. https://en.wikipedia.org/wiki/Cre-Lox_recombination . But I really don't know the subject matter well enough to tell yet if they're talking about using the enzyme or whatever to do gene splicing on the embryo or whether it can be done during an animals lifetime (or how that might interact with immunology, etc).
--update -- reading up on the cre-lox process here https://www.jax.org/news-and-insights/jax-blog/2011/september/cre-lox-breeding-for-dummies seems to indicate that its usually done to the parent, and then the kids have the modified genes. Foo;P
Just.. theoretical biohacking here, I'm not crazy enough to try this (I don't think). Unless I was able to do it to a mouse, but I'd kind of feel crappy about doing that to a mouse, even, and I have a pet snake, so I'm not all that nice to mice.... just, wishful thinking + curiousity mostly
It looks like in mice this was achieved using, well, tamoxifen inducible cre transgenic mice + tamoxifen, but I really don't understand cre/lox recombination.. found a wiki on it here that gives me a few clues. https://en.wikipedia.org/wiki/Cre-Lox_recombination . But I really don't know the subject matter well enough to tell yet if they're talking about using the enzyme or whatever to do gene splicing on the embryo or whether it can be done during an animals lifetime (or how that might interact with immunology, etc).
--update -- reading up on the cre-lox process here https://www.jax.org/news-and-insights/jax-blog/2011/september/cre-lox-breeding-for-dummies seems to indicate that its usually done to the parent, and then the kids have the modified genes. Foo;P
Just.. theoretical biohacking here, I'm not crazy enough to try this (I don't think). Unless I was able to do it to a mouse, but I'd kind of feel crappy about doing that to a mouse, even, and I have a pet snake, so I'm not all that nice to mice.... just, wishful thinking + curiousity mostly
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Especialy in humans. But maybe in the next couple of decades.