The Big Hack (part 1: coating)
This first part will deal with coating and the procedure of implementation.
RESEARCH (more will be added as I learn more) :
http://www.sciencedirect.com/science/article/pii/S0169433210016272 (Thank you @chironex, this was very useful when I first started looking into transdermals)
PROCEDURE:
The procedure in itself is quite a simple idea take off the skin and shove some technology in its place , but to be effective it requires much more than that.
1. To start you are going to want to reduce blood flow by whatever your preferred means are so long it doesn't interfere with anesthesia
2. Apply local anesthesia to the area where the implant will be and allow it time to fully numb the area.
3. Remove the skin as one would if he was getting scarification ( for those who don't know what scarification is : DON"T WATCH IF YOU ARE EASILY QUEASY!!)
4.create the necessary microscopic holes in the flesh beneath
5. place the technology (which have live epithelial cells bound/ grafted/ whatever you want to call it to it) in the area where the skin was.
6. Bandage
7. Wait for it to heal
COATINGS:
The coatings that I am currently working on is composed of a mixture of the following :
Chitin (Is known to help speed the healing process )
Chitosan
Hydroxyapatite
Collagen( also helps speed healing and is a large part of the skin)
Fibrinogen ( to help blood clot and form a scab)
a minuscule amount of hydroxyapatite suspended inside of it
9. allow it to evaporate
10. repeat 8, and 9.
Tagged:
Comments
I like the idea, I am curious (I assume you may have found out in your research), any thoughts on what would happen if you removed the skin, placed something in it's place, and held it there, with say, a strap or bandage, for weeks. Would Skin start to grow under it, thus pushing it back up? Would Skin grow around it and then stop, regardless of if it bonded with the skin? What if you had something smaller, like a needle, that went below the skin layer, I think it's safe to assume that skin wouldn't grow back under that, but would the skin grow healthily around the needle if you were able to keep the area clean?
I know it's a little off topic, but it seems a similar field of research so I thought I'd ask.
On topic, you mentioned attaching to bones, in which way did you intend on doing that? Similar to most medical implants I assume? (Little screws)
Why scarification? Is there specifically a reason to do that kind of damage?
If you still have a foot to grow how old are you...and can you explain the goal of what your trying to accomplish and what the benefit of it might be? Also just for aesthetic reason add some space to the links so it's easier to navigate with maybe a header for what each one covers.
So my understanding is that you are attempting to make a mounting plate for future attachments to the body?
I wasn't aware you hit the limit for words. Have you considered maybe a small test implant to see how well it will attach to the body? Small scale then move up.
What's the method of fusing to the object?
My posts to this are to get make things clear on what you are planning/trying to accomplish nothing more which is why I haven't given any true input on what to do.
Back on subject now...
so your device would in fact be more the mouse and keyboard to a computer then anything else (sticking with analogies), which is to say for input. You would then have some sort of external feature that could manipulate that implant I assume? Does that mean you have an idea for attaching said doohickey to it? Perhaps magnetic or a clasp that not attached to the skin?
I use very official words if you haven't noticed ;)
EDIT:
My emoji didn't work had to come back and fix it.
If your transdermal has to be flexible and have moving bits that will effect what you use for a coating.
@Zwytechhacker Your coating process will still have issues. You will get a membrane, it's true, but NaOH is not a crosslinker of chitosan. If you read down in the conclusion of this paper, chitosan is not mentioned. I would suggest crosslinking your chitosan before applying the HA. @chironex and I have both noticed structural instabilities when using unlinked chitosan.
and another vote for bendy being important. Please refer to my blurb from a while back when someone talked about puting hardware where their appendix used to be.
http://forum.biohack.me/discussion/comment/5035#Comment_5035