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Comments
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Herpes simplex is some sort of retrovirus so I'm not sure whether or not it can bypass the nuclear membrane which means it might only be able to integrate into dividing cells only. However my main concern at this point is cost effectiveness. As yashgorath pointed there is no practical way to deliver a gene vector to every…
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The main reason I want to use a lentivirus is that they can transduce non dividing cells whereas adenoviruses can only transduce dividing cells. Do you know if a fusion protein of GFP and some other protein is necessarily cytotoxic?
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Some very good points. As you said telomerase isn't an oncogene. It is more the case that telomerase expresion is necessary for most cancers to occur but is not in of itself sufficient to cause cancer. If somatic cells did constitutively express telomerase then it could be argued that the risk of cancer developing would…