A possible cure for Parkinson disease?!
I was bored today and was thinking about Parkinson for some odd reason. Correct me if I am wrong, but it is caused by a decreased dopamine secretion in the substantia nigra in the midbrain? If so injections of dopamine into the body should help deal with the symptoms.The reason we do not do that however is because the blood brain barrier (her by called BBB), as dopamine can not go through it. But aluminum can....Which is the base of this theory. If we could find a way to dissolve the aluminum in the brain, we can inject dopamine in an aluminium shell, and then dissolve it allowing dopamine to be released in the brain, curing the symptoms of this disease. Thoughts?
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L-Dopa has horrid side effects, and people build up a tolerance decently fast. Dopamine however has fewer side effects, and has a rather slow tolerance rate. Correct me if I am wrong, but isnt Parkinson's disease caused by the inability to produce dopamine, instead of being unable to absorb it?
In terms of side effects of L-Dopa vs. Dopamine... it's a very similar thing. List of medication side effects are very route specific. Anything being listed re: dopamine is about the side effects of peripheral administration. Were you to instead administer it centrally... it would in fact have more central side effects than L-dopa. I don't believe L-dopa exerts any action in and of itself. All psychoative effects are related to what it does after conversion to dopamine.
So anyways, there's a frontal lobe region asociated with executive functions which has been linked to Schizophrenia when high levels of dopamine are present. Thus, when a person takes Sinemet (Levadopa/carbidopa) a possible side effect is schizophrenia like symptoms. When someone takes typical antipsycotics... parkinsonian symptoms are common.
One more weird thing... if you inhibit dopamine even men start lactating. At some point there was some post regarding feeding the starving children somewhere... I guess this could a Grinder past time assuming you feed them from your own body.
Dude, it's grinder soylent