siRNA Gene Silencing
siRNA has been successfully used in gene silencing therapies since 2018 and it is really starting to gain traction in the pharmaceutical industry. My question is could this technology be used to silence the gene for myostatin production? It seems like silencing the gene would be a safer and easier approach than trying to remove the gene or adding something new. I know most of the therapies on the market currently target the liver and earlier siRNA treatments accumulated in the liver. What would need to be done to the delivery system to make it target the muscles? What safety concerns should one have for such a project?