Orexin-A Group Purchase .
I've currently been sourcing human Orexin-A from many sources . I've come to find that synthesizing such a complex neuropeptide is quite expensive , but I've finally found a lab willing to synthesis a smaller quantity than most labs are willing to , in hopes of further purchases of a larger quantity . It's relatively inexpensive and of a reasonable quality %98-99 purity . Priced at $340(USD) for 200Mg. Which may not sound like much but considering how potent the compound is (active at around 200µg or .00002mg , 1mg would equal about 5000 doses ) 200mg for $340 is quite a bargain . For those not in the know , Orexin-A is a neuropeptide found in the human and animal brain , current studies suggest that a deficit of Orexin-A may be responsible for narcolepsy . Supplementing with Orexin-A while in a sleep deprived state increases alertness , cognitive ability , and arouseal among other things
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It's highly conserved so genotoxicity may not be a huge deal. Let me set out this warning though.. a number of protein drugs have resulted in deaths during trials. If your body recognizes it as foreign and makes antibodies it's lights out. The antibodies bind to your own orexin. Be cautious.
A few things you might consider reading:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113840
This is a pretty good intro to endotoxins and why they matter when dealing with recombinant proteins.
I'm not anti-china.. but once I ordered a batch of "Parylene" coated magnets than ended up being coated in a really nasty cytotoxic resin. Because cytotoxins most certainly can cause pronounced effects, I'd definitely be interested in what tests/assurances of purity etc. we could get.
And another: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm338856.pdf
This is an ok guide on Immunogenicity testing with an overview. Both are worthwhile to read before considering self-administration.
Also, if you/we decide to go through with admin, have you considered what measures you'd like to test? I would think normal vitals (BP, HR, RR, Temp), add in perhaps blood sugar (it has metabolic effects), Daily weights.. Blood labs aren't too much and I believe you can have them performed w/o MD order.
Example: http://www.walkinlab.com/catalogsearch/result/?order=relevance&dir=desc&q=complete+blood+count
It's like 24$ bucks assuming this is a real site and there isn't some catch I'm missing.
I'd probably at least go for a CBC, BMP, and perhaps a lipid profile.
Cognitive tests would be a definite go to.
I'm not sure what kind of testing would be appropriate regarding its effect on sleep and wake. I know someone who used to run a sleep lab though so I'll ask her if she has any ideas.
In terms of administration, you might look into an MAD device like this:
http://www.mountainside-medical.com/mad-nasal-intranasal-mucosal-atomization-device-without-syringe.html?src=b&gclid=Cj0KEQjwg9-vBRCK7L7wmO2u0JcBEiQA_tzoaGHRMd-c3HDU5Bcp_6Yap-Dt1c4TbjAu8URJAfh5GuIaAmln8P8HAQ
Basically, they attach to a syringe and you can atomize very exacting amounts in a fine mist that works better than snorting through a hundred dollar bill or spritzing.
we had better have a test to be sure which one happens to us.