Nerve Growth Factor for proliferation of sensory neurons
5/2/15 M31s were implanted into the Ring fingers of both Glims and cassox via scalpel method. Glims is serving as control and recieved no Nerve Growth Factor (NGF) of any form.
The M31 implanted into cassox (sorry 3rd person from now on out of conformity) after administration of 5 ug of Beta- NGF dissolved 0.5 ml 0.9% solution of NaCl directly into the incision site. An additional 5 ug of B-NGF in solution was injected subcutaneously 5 mm proximal to the incision site. We hypothesize that the NGF will facilitate quicker neuron growth/regrowth, quicker time to sensitivity, and a chronic/long term increase in sensitivity/effect provided by the implanted magnet. Initial injection was painless but resulted in a "fuzzy" feeling in the hand. Throughout the initial 12 hours following administration pain progressed to 3-4/10 throughout the effected digit as well as to the fingers to either side. Pain was distinct from incision pain. No acute swelling or reactions noted. Vitals remained stable and within normal limit.
Narrative - ( Still haven't found that perfect balance of writing research and writing for readers) So NGF is a family of proteins associated with growth, maintenance and neuron proliferation. There's been quite a bit of research regarding it. I'll post some of it below. One example of NGF dysnfunction is found in a condition called HSAN5 which results from a mutation in the gene which codes for NGF. Children born with HSAN5 are unable to sense pain which often results in self-mutilation, for example eating through their own lips and cheeks.
NGF is also found in the venom of male duck billed platypus. Its neither necrotic nor neurotoxic,but platypus venom is described as being painful enough that people killed themselves to end the pain. The NGF in the venom causes the local sensory neurons and the sensory pathways to the brain to be "reinforced" (this is a colloqual/short hand way of describing some research indicating increased axonogenesis and nerve proliferation etc. If this description doesn
t do it fer ya, please read the included reference reasearch). Research has shown that people are significantly more sensitive to painful stimuli. Other sensory modalities appeart to also be postively effected such as the sensation of pressure, while others such as the sense of vibration is not.