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I know this is an old thread but I wanted to discuss a fewideas I’ve had for improving magnet coating biocompatability. I am studying biomedical engineering andchemistry and have access to a good number of chemicals in my lab.
An easy option would be to take the D1005A Parylene-C coatedmagnet and coat with polyethylene glycol. PEG’s biocompatibility has been thoroughly researched and it is alsoextremely hydrophobic, which would minimize foreign body response leading tomagnet rejection. This double coatingwould minimize the risk of pin-hole related rejection, can be applied thinly andwithout heating, which would retain magnetic strength, and is also costconservative. Research indicates that itfunctions well in combination with Parylene-C and stands the test of time. (http://www.sciencedirect.com/science/article/pii/S1607551X11002397)
Alternatively, the same Parylene-C coated magnets could becoated with SiO2 which would show the same benefits- low heat bonding,inexpensive, and a thin layer of durable, biocompatible material. This would also open the possibility ofcloning a silaffin R5 tag on, which would catalyze silica formation andessentially act as a self-repairing coating. I’m not sure whether this would remain localized on the implant, but Iworked with an R5 modified protein previously for immobilization and saw greatresults. (http://iopscience.iop.org/article/10.1088/0960-1317/21/3/035011/pdf)
One final option- though this I would not be able to do withmy resources- would be to coat a magnet in TiN and follow with an additionalcoating of Parylene-C.
As a side note, silver should not be used as a coating. The reason why silver is antimicrobial isbecause it is toxic. A very thin coatingwould not cause any lasting harm, but it also would not be a permanent coatingand would inevitably expose the body to the neodymium.
Any thoughts and input is much appreciated!