Help with Serums?

I am investigating life extension via immunization of the human body from 8-OHdG. This causes DNA oxidation, and in lab tests on mice and rats, blocking 8-OHdG from activating slows the damage of the brain, muscles, bone structure, and liver. Question: Is it possible (within ~20 years) for an implant to actively produce and introduce a Anti-8 Hydroxyguanosine antibody into the human body?

Or, simplified, could it be feasible an Implant to produce serums?



  • 8-OHdG is a small molecular chemical structure and we can target it with an antibody at this point
    It seems that it is specific to 8-OHdG so that's good. At the bottom of that page are links to papers where people have introduced the antibody into subjects and reduced a variety of issues. Of course, like always, these were done on already damaged systems, but there doesn't seem to be any reason why it wouldn't work to reduce damage to healthy subjects. Testing that would be... a very long term project.

    I am under the impression that we make some of this stuff ourselves. However, it is only in small amounts. Simplified, we burn the wood faster than we sweep out the ashes. 

    Options I suggest exploring are upregulating the production of the antibody or just injection.

  • Thanks so much, you're a godsend. 
  • I'm liking the idea of upregulating this if we do produce it. thoughts?
  • Up regulation could mean a whole other slew of effects. Let's see if we can get this idea rolling first and then pull out the big guns.
  • An implantable drug delivery device is actually something I've been interested in. It doesn't seem to be to difficult to replicate something similar to Implanon/Nexplanon ( with a different payload. I read the patent, and manufacturing looks to be a relatively simple process.
  • Thanks for bringing up Nexplanon, @CitrusBolt; I was thinking, doesn't this exist already?
  • These articles may be of interest Re: life extension. I can't see the method described in the articles working as an implant but thought it may be worth mentioning.
  • I've also pondered something using internal drug delivery, but for nootropics and vitamins.
    @CitrusBolt can you summarise your findings on the contraceptive implant?
  • I was looking into it for the same reasons. Obviously, your payload has to be something with a pretty low dose depending on the implant lifetime and size you're going for. Selegiline, BPAP, maybe Coluracetam were what I was imagining. B12 might be a good candidate for a prototype, depending on how available and accurate blood tests are. If we become super confident in our technique, a constant microdose of LSD might be worth investigating.

    The coating is ethylene vinylacetate (EVA). The core is a mixture of EVA and your drug of choice. If I recall correctly, it is that simple. I assume that the ratio of EVA to drug determines the rate that the drug diffuses through the coating. I imagine a very rough mockup could be made in a kitchen. Some sort of extruder would be necessary for the final product. I haven't done any research into the actual equipment used, but I wonder if it would be feasible to utilize the kind of extruder used in 3D printers.

    I'll have to look into how the absorption rate is calculated.
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