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Yes. We've identified a few potential methods to circumvent the need for long-term VAD dieting, but as glims mentioned it's not the primary focus right now. At this point, it's really proof of concept. There has been a lot of different research performed similar to this. The majority was prior to the 1960's and lacked access to the electrophysiological measures that we'll be using. Some animal studies showed as much as a 95% replacement of Rhodopsin with Porphyropsin. Now, while I won't let myself even hope for such an awesome result, at 95% porphyropsin a person would have vision equivalent to a Tilapia. A Tilapia can see up to about 950nm. Humans see up to around 700nm. The difference between something that we percieve as orange, and something we percieve as yellow is about 30nm. So a tilapia sees around 8 colors worth of spectrum above us.
Now, I slightly misrepresented the data in that last statement. There really hasn't been much research at all pertaining to photopsin incorporation of 3 4 dehydroretinal. Assuming that we do end up with a significant amount of porphyropsin formed in the retinal cells, we'll be able to "see in the dark." That much has been confirmed in animal studies. Mice/rats end up with significantly improved dark vision. The part I'm particularly interested in is whether or not there will be any changes to high acuity color vision. I can't concieve of a color I haven't seen before. In fact, neither can you. Its outside the brains capability. So is it possible that subjects will experience some new novel color experience? Will the spectral shift simply be interpreted by the brain in terms of colors we already know? Or will there be no change in color perception at all? This is something I hope we will be able to answer.