Substances for different metabolic types
I'm a rather strong believer in utilizing pharmacology (and especially psychopharmacology) to not only cure ailments but enhance or improve bodily function (legally, of course). However - and I was wondering if anybody else on this board deals with this and couldn't find an older post about it - my body's metabolism makes this difficult as an ultra-rapid metabolizer.
(As you all are intensely familiar with your own bodies and anatomy in general I'm sure I don't need to post this but just in case: chemicals are broken down by different metabolites in your liver, and very many pharmaceuticals use a small handful, especially CYP2D6. You can get expensive tests done to establish the type of metabolizer you are [poor, intermediate, rapid, and ultra-rapid, with rapid being the most common] which depends on how many copies of certain genetic enzymes you have, though I found out after some research, an... interesting experiencing taking [legally prescribed] Rx codeine-based cough medicine during a particular bad cold, and then examination of my own DNA data.)
Even caffeine and other simple things have no effect on me - I tried, in my trial and error phase, taking two NoDoz and one of those "SUPER" energy drinks for probably a total of ~440mg of caffeine at once and still found myself sleepy on my morning commute. Many pharmaceuticals have a similar negligible effect. My saving grace is in prodrugs (again, probably not necessary to clarify but: most drugs function after intake and the liver metabolizes them out of function - prodrugs function after being metabolized by liver, causing longer duration and decreased intensity in most people but increased and faster administration of the active metabolite in people like me - e.g. I (again, legally) take Vyvanse/lisdexamfetamine, which is a prodrug of dextroamphetamine and at my current dose of 70mg PRN it turns me into an entirely different person almost, increasing my function, drive, sociability, creativity, physical energy, and of course wakefulness, etc.).
So - as you can imagine, many supplements and nootropics don't function in me the way people claim they should (I never tried modafinil because after being prescribed I realized it would potentially decrease the bioavailability and thus the function of my birth control which I very much do not want, ha).
I was wondering if anyone else here deals with similar problems and if so, if there are (AGAIN, legal) supplements/nootropics/OTC products, etc. that might have a better chance of working on ultra-rapid/ultra-extensive metabolizers (without extensive contraindications/negative reactions with birth control, haha). So far I'm happy with how Vyvanse enhances my entire self, but it would be interesting to experiment with different options, especially since Vyvanse isn't particularly cheap as a brand name pharmaceutical.
Thank you in advance and I hope this prompts some interesting and helpful discussions for others as well!