Viral Editing?

Hi guys,

   I am a 4th year biotech UG with an interest in viruses. The herpes simplex ll virus cure was found by genetically removing a protein used to cloak the bodies immune response to prevent production of anti-bodies, the Gd2 protein. 

I want to test this in mice, but I am not sure where to even begin?

Is there is a site I can order the modified virus in vaccine format for research? Subsequently, what if I wanted to test this on other viruses to removing cloaking mechanisms, how would I cut out a piece of virus RNA/DNA?

Comments

  • edited January 11

    I would start with CRISPR. It's the most widespread/accessible method for cutting out specific genes from a segment of DNA that I am aware of. I'm no CRISPR expert, but it's probably worth looking into.

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