How to synthesize Spider Venom(s)?

Was reading an interesting article about using spider venoms as non-toxic pesticides. I want to test a natural pesticide/plant growth enhancer using a mixture of chitin/chitosan and spider venoms. Getting chitin is the easy part, but does anyone know how to synthesize spider venoms? Crudely attempting to "milk" spiders is not an option. Chitin/Chitosan has numerous biocontrol applications (tested by NASA) and I'm trying to develop safer pesticides so that agriculture doesn't need to use sketchy things like glyphosate or atrazine for example.


  • this is a heavy duty project that without PhD level knowledge and tech you probably won't be able to accomplish. But try to connect with @chironex he probably is too busy rn with his sider silk project but him, Josiah Zayner, and David Ishee are all pretty good at genetic engineering which is probs the best route (get a single-celled organism to make it then extract it)

  • There's a lot going unsaid as well. What spider? What specific component of its venom? And.. are you sure that this is less harmful then currently used pesticides? "Natural" doesn't necessarily mean better. Many of these venoms are neurotoxins. Sure, we only worry about them when administered via a bite.. but I'm not sure anyone has had a gallon of the stuff around. What would happen if you had a few ounces on the skin?

  • The venom is a extracted from the Blue Mountains Funnelweb Spider and the specific extract [Hexatoxin-HV1A] from it is proven to be nontoxic to humans and bees.

  • Interesting. Do you know if it get absorbed on contact by insects?

  • I'm honestly not sure, though everything I've read on it mentions ingestion or injection.

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