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J147- a neuroprotective compound that might also reverse aging (in mice)

crazyivan
crazyivan
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November 2015
edited November 2015
in Supplements, pharmaceuticals, and nootropics
Looks like a promising neuroprotective molecule, J147, is back in the news and I was wondering if anyone in our community has tried it or critiqued the articles. For those who don't know about it, J147 is an orally active neurotrophic compound that was shown to reverse Alzheimer's disease in mice models a few years ago and so far seems pretty safe. 

Recent studies also appear to show that it can reverse aging in mice making "old mice look like they were young, based on physiological parameters." Additionally, it can already be purchased on alibaba.com or cellagentech.com, so there is potential for a future group buy.

http://www.salk.edu/news/pressrelease_details.php?press_id=2130
http://www.impactaging.com/papers/v7/n11/pdf/100838.pdf (PDF WARNING)
http://www.ncbi.nlm.nih.gov/pubmed/23673233 


Tagged: J147, nootropics, Alzheimer's

Comments

Displaying all 9 comments
  1. bciuser
    bciuser
    November 2015
    While this is cool, bear in mind there is no reason to believe this would have any affect on the brains and vasculature of young individuals, given the drug was only ever tested on old mice. The most recent article has some pretty exhaustive assays tho. 
  2. ChrisBot
    ChrisBot
    November 2015
    Well, any volunteers to buy some and try it?

  3. Cassox
    Cassox
    Second Anniversary Third Anniversary Fourth Anniversary Fifth Anniversary Final Anniversary First Post First Anniversary 100 Posts You Look Familiar 1000 Posts 500 Posts 10 Posts Welcome Committee Paging Mr. F Have Some Cake We Have Touchdown I'm Not Dead Yet!
    November 2015
    Interested. I'll read up on it. If I don't find anything I don't like id be down.
  4. garethnelsonuk
    garethnelsonuk
    November 2015
    Let me know if there's a group buy, I might want in on it too after researching.
  5. ChilliEye
    ChilliEye
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    November 2015
    Me three.
  6. glims
    glims
    First Anniversary Second Anniversary Third Anniversary Fourth Anniversary Fifth Anniversary First Post 10 Posts 100 Posts 500 Posts 1000 Posts You Look Familiar Welcome Committee Final Anniversary Paging Mr. F
    November 2015
    Oh! it's a curcumin anlaog, right? Looks interesting, if maybe a bit steep... Mice were fed 10-20mg/kg/day. So, if we are trying to match that... I'm 100kg.... that means I would need to eat a gram a day on the low side. That's 100 dollars a dose. One would need ot look into how low a bulk buy could possibly get that...
  7. U9Z0
    U9Z0
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    November 2015
    Also interested in a group buy if it ends up happening. 
  8. chironex
    chironex
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    November 2015
    I poked around the literature a bit. There's a fair bit about j147 but more often people have been studying it's derivatives and improving on it rather than going for the initial compound. Just a thought if we're gonna try it. We may wish to look at a well studied derivative. who knows it may be cheaper if someones got loads kicking around
  9. garethnelsonuk
    garethnelsonuk
    November 2015
    $100 a dose is a bit beyond budget.......
Displaying all 9 comments