Cognitive enhancement and sleep mod: Vasoactive Intestinal Polypeptide
VIP is a neuropeptide with many different roles in the body. Most pertinent to us is its role in the suprachiasmatic nucleus; VIP is THE substance underlying our circadian rhythms. VIP has a peak and a trough each day, something like sands in an hour glass. Murine model research has shown that supraphysiological doses can act something like a reset button. Basically, once administrered your brain no longer know what time it is and looks to stimuli to determine what phase it should be in. So basically, your going to work tommorow night? Take a dose and (assuming it works, never been used in humans) your body is convinced its whatever time you decide. This has a lot of potential. Can be we change the duration of rhythms? Can we dose multiple times and make a 10 hour running pattern? A 36 hour running pattern? I don't know, but it very well could. Perhaps more interesting is its potential effect on cognition and memory.
The available data is really mixed on its cognitive effects. There seems to be a short duration amnesia associated with it in the CNS. However, it reverses the effects of both scopolamine and induced rat alzheimers. In the long term, it seems to significantly increase memory formation/recall. The reason appears to be that it significantly increases the duration of both REM and SWS.. the periods when memory consolidation occurs. So, immediately amnesia because memory formation and consolidation can't co-occur.. long term benefits because from that point on you have very solid consolidation. Once again, this is somewhat speculative. I'll have a post up within a day or two on Augmentationlimitless.com with a shit load of data.
In terms of safety, it's.. an unknown thing. The peripheral effects are pretty crazy. Hypotension to the point of death, diarrhea to the point of electrolyte imbalance and death. All your exocrine glands go into overdrive. Females have like 80% greater secretions etc. A few human trials with the stuff have occured. For example, theres a study on the effects of inhaling the stuff to treat a lung/resp condition. However; it's never been administered in humans directly to the CNS. The way we are doing this is via the intranasal route. It has been shown an effective route via isotope tagging when administered in conjunction with some other stuff that you can read about in the write up if your interested.
The first trial of this substance is slated to occur on the 29th of this month. Cyberlass is taking point against all my advice to the contrary. Ha.I'll also be dosing as will Proteus Mark. We have a lot of stuff in place. Crash team and whatnot although I really doubt any really bad event is going to occur. This is imho the most promising nootropic type chem I've seen. So, we talked about it and thought we'd start recruiting for the phase two trials. Of course, this stuff isn't terribly cheap. Assuming no one gets fucked up during the first phase, we're looking for people interested in the next run. We'll have purchased most of what needs buying except for VIP itself. The cost is around 200 for an appropriate dose. Keep in mind this isn't a short term chemical. One dose and your looking at potentially 30 days or so of action in the CNS. Let me know if your interested in participation. Also, this is being recorded by MTV for the Nootropics episode.
The available data is really mixed on its cognitive effects. There seems to be a short duration amnesia associated with it in the CNS. However, it reverses the effects of both scopolamine and induced rat alzheimers. In the long term, it seems to significantly increase memory formation/recall. The reason appears to be that it significantly increases the duration of both REM and SWS.. the periods when memory consolidation occurs. So, immediately amnesia because memory formation and consolidation can't co-occur.. long term benefits because from that point on you have very solid consolidation. Once again, this is somewhat speculative. I'll have a post up within a day or two on Augmentationlimitless.com with a shit load of data.
In terms of safety, it's.. an unknown thing. The peripheral effects are pretty crazy. Hypotension to the point of death, diarrhea to the point of electrolyte imbalance and death. All your exocrine glands go into overdrive. Females have like 80% greater secretions etc. A few human trials with the stuff have occured. For example, theres a study on the effects of inhaling the stuff to treat a lung/resp condition. However; it's never been administered in humans directly to the CNS. The way we are doing this is via the intranasal route. It has been shown an effective route via isotope tagging when administered in conjunction with some other stuff that you can read about in the write up if your interested.
The first trial of this substance is slated to occur on the 29th of this month. Cyberlass is taking point against all my advice to the contrary. Ha.I'll also be dosing as will Proteus Mark. We have a lot of stuff in place. Crash team and whatnot although I really doubt any really bad event is going to occur. This is imho the most promising nootropic type chem I've seen. So, we talked about it and thought we'd start recruiting for the phase two trials. Of course, this stuff isn't terribly cheap. Assuming no one gets fucked up during the first phase, we're looking for people interested in the next run. We'll have purchased most of what needs buying except for VIP itself. The cost is around 200 for an appropriate dose. Keep in mind this isn't a short term chemical. One dose and your looking at potentially 30 days or so of action in the CNS. Let me know if your interested in participation. Also, this is being recorded by MTV for the Nootropics episode.
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Sincerely,
John Doe
And disconnected to tv is no film crews.
Hum that's interesting, I actually am completely clean and suber so now I am wondering if there's not something in my diet....
kratom its wven more vicid and I can remember the melodies and everything. It maybe dietary, but, you make music too correct? So it might just be something music makers experience.
On that note I bow hunt (no real bearing aside from state of mind) from a tree stand which I get in around 3-4am depending on the shooting times but well before sunrise. I'm normally still groggy and haven't even spoke or really eaten anything but I tend to have a lot of ideas/designs during that time. My last one was for a new style of arrow rest which I'm still trying to get right. My mind is generally quiet during that time until I get that idea which just kinda pops in there and I can't shake it the rest of the day (You should see my note books some time lots of sketches and plans).
I hope that might help with narrowing it down. My thought is that there is low-no light which allows little to no distraction so you don't have your mind running circles like a child on too much sugar. Same with when you wake up it's still a quiet mind. I guess you could call it almost meditation.
http://daringtolivefully.com/how-to-enter-the-flow-state
https://en.m.wikipedia.org/wiki/Flow_(psychology)
https://www.psychologytoday.com/blog/the-playing-field/201402/flow-states-and-creativity
It make sense, but I feel left with more questions than answers. Running with what all three of us are saying it almost seems triggered more than entered.
Sincerely,
John Doe
PS if this keeps up I think we should go start a new thread, lukeo has already asked about something similar.