• glimsglims November 2014
    Update for those of you who got interested in the NIR eyedrops (ref NIR thread) using Ce6 as a light increasing mechanism:

    We should have them ready soon. Basically, I'm just making sure that I can get the amounts right and not scorch your eyes. The papers and patents we have access to are very specific in some regards and very vague in others. As @Cassox mentioned, this chemical is used in lazering cancer cells (my paraphrase) so obviously, exploding your eye bits by tiny molecular focuses of daylight would... suck.

    Progress is being made. It's just me reading and then mixing things together and measuring light bits.

    For those who are ready to chip in and talk about that patent, their amounts are theoretical and were used just to lock the patent down. Got get this right so nobody gets hurt. Eyes are important

    Anyone have any questions, let me know.
  • DeusExLiberDeusExLiber December 2014
    When you have the recipe fleshed out will you post it?
  • glimsglims December 2014
    Of course. I'm actually expecting some of you more science minded folks to pick at it a bit. I should have more updates by this time next week.
  • glimsglims January 2015
    So, a cool update on the eyedrops.
    We've been struggling to understand why the patent uses insulin as a transporter. Like, why insulin? It shouldn't change permeability or anything.

    Turns out that there is a paper about how ABCG2. ABCG2 in turn, inhibits Ce6 transport. So by using insulin instead of saline or something else, it actually the Ce6 to get absorbed into the eye! I'll drop the paper into the community folder if anyone is interested.
  • AgemFrostMageAgemFrostMage February 2015
    What are the visual effects and what nm range are the eye drops sensitive to?  Sometimes I do infrared photography with a Sigma camera and trees look pinkish red and more stars can be seen and am wondering how they'd be similar and different to the eye drops. 
  • glimsglims February 2015
    A great time to do some more updates. DirectorX was down here the other day and we were brainstorming about how to go about testing these drops for effectiveness.

    You see, the thing is, we aren't sure if the drops will just work merely as a light amplifier in general (dim becomes bright, etc) or if due to a photon shift (the mechanism for light amplification is a bit odd for this thing) we will be getting vision outside of normal range.

    The short answer is, I can't answer your question, sorry.

    Doing some testing today. vials will be mailed out shortly. Almost done, finally!
  • TimmyCNinjaTimmyCNinja February 2015
    Please be sure any info that was discovered here, and any information that comes out ends up with a wiki entry for CE6
  • glimsglims February 2015
    Will do! Thanks for the reminder

  • AgemFrostMageAgemFrostMage February 2015
    It's okay.  It's fun to speculate on the effects though.  I put Congo blue gels behind my sunglass lenses because even during the daytime some cars now have their lights on and it's annoying so it greatly cuts them down and vastly reduces the distraction.  One can't see green or yellow with them but yellow looks like a weird pinkish red color while green is a bluish gray and trees that are normally green are...pinkish red?  Yes, don't know why.  What does this have to do with anything?  Simple, the infrared will likely create similar effects but without the green cone color blindness.  I'm not saying definitively the drops will be like that but is a personal hypothesis. 
  • zombiegristlezombiegristle February 2015
    Any updates on these drops? I'm looking forward to trying this out.
  • glimsglims February 2015
    We have mixed them, tested them, and are in the final tests to see how well they work. We have passed the oh god oh god my eyes section and now are in are in the oh does it actually work phase
  • zombiegristlezombiegristle February 2015
    Those are the best descriptions ever. XD
  • TheGreyKnightTheGreyKnight February 2015
    Hooray! I don't know if I'll buy some of the first batch, but if we distribute the recipe, I'll probably try my hand at making some. 
  • bciuserbciuser March 2015
    Definitely sounds like something I would buy, about how long would one package/bottle/quantum of eyedrops last? Any permanent effects or is it entirely temporary?
  • glimsglims March 2015
    The paperwork says 2 hrs up to peak efficiency, 6hrs down. THere has been no testing about how that would be measured, but that's what we have to work with.
  • @TheGreyKnight

    I looked up the extraction process for Ce6, you need very specialized (presumably very expensive) equipment and a long time for it. 

    "


    The following procedure was reported in
    Oncology Reports, 2009, 22(5). 1085-1091 by
    Korean scientists Yeon-Hee Moon et al.

     
    Live chlorella (Chlorella ellipsoidea) 100 g (dried weight) was
    sequentially washed with 500 ml of water and 300 ml of 50% ethanol in
    water to remove polar materials and the residue was extracted twice with
    500 ml of 100% ethanol to obtain chlorophyll a rich fraction (extraction
    yield 4.3%). Stirring the combined ethanol solution of chlorophyll a in
    1 N HCl (pH 2.5) for 3 h at room temperature afforded pheophytin in the
    form of precipitates. The precipitate was dissolved in dichloromethane
    washed with distilled water, dried with anhydrous sodium sulfate, and
    rotary-evaporated to dryness. The residue was purified by a
    chromatography using neutral alumina (Aldrich, Brockmann, ~150 mesh)
    with a gradient elution from 30% dichloromethane in n-hexane to 100%
    dichloromethane. The main green band was collected and evaporated to
    dryness. The crystalline powder was dissolved in acetone, adjusted pH
    12.0 with 1 N NaOH, and stirred for 12 h. The precipitated Ce6 was
    filtered, washed with acetone and dissolved in 100 ml of water, and
    filtered to remove insoluble impurity. After lyophilization of the
    filtered water solution, a fine black powder of Ce6 was obtained. The
    purity of Ce6 is 93-98% (yield of Ce6: 1% from dried weight of
    chlorella
    )"

    From

    http://www.medkoo.com/bio-reagents/ChlorinE6.htm

    Otherwise it would sound like a wonderful home project.  I'd love to order some drops too but if they're out of my price range I can understand why. 

  • I wasn't planning on isolating the compound itself (though the various chemicals don't seem too pricey, and I'm sure my university lab would love to let me have a go at this) . Though I cringe at the mention of a roto-vap system, because I've heard they're very pricey.
  • GriskardGriskard March 2015
    Cmon guys, just jam that shit in your eyes and let us know the results!
  • bciuserbciuser March 2015
    @AgemFrostMage the only procedure that requires expensive equipment is the lipholization (freeze drying) of the compound, requires some pretty expensive equipment. All other procedures and chemicals are readily available organic and inorganic solvents, and you would only need some Erlenmeyer flasks, separatory funnel, magnetic stir bar with a hot plate, and a couple other pieces of glassware for the chromatography. Could probably get everything except the freeze-dryer for a relatively low cost.
  • glimsglims March 2015
    @Griskard Shit has been jammed in eyes and the results are in :)


    We are keeping a little bit for further testing to get some serious quantitative data, but at this point, I am saying this is a legit hack. Night vision successfully increased (subjective, but also I'm pretty sure I could take you out in a forest). No NIR that we know of. Effects wear off after 6 hours.

    Those of you who chipped in, I am bottling that stuff in a day or two after I recover from Grindfest, and then whoosh off it goes. I will have a sheet of proper applications care etc and Cass will be fact checking my work so you guys don't lose an eye.

    I'm gonna say this now. Do not do this during the day. Seriously.

  • I've forgotten how many doses I ordered, but for future reference do you have any plans to coordinate with @Amal and sell these throughDangerousThings? Or to put it another way, is there a way for us to order more if we like what we see? Can they be stored in the freezer or a wine cellar to "stock up"?
  • ChilliEyeChilliEye March 2015
     Any left up for grabs? I thought this would be miles off and didn't realise everyone had stumped up already. Depends on cost shipped over the pond though really.
  • chironexchironex March 2015
    What ended up being the final "recipe" as it were. Did you end up using insulin?
  • Well, if I understood him correctly, Insulin was a requirement for the drops to work.
  • Seconding the interest from ZombieGristle here. I didn't realize how quickly thing were moving. Any plans for future batches?
  • glimsglims March 2015
    Well it turns out that I may have a little bit more than planned due to getting some for testing. PM me 
  • glimsglims March 2015
    Just to answer the question that keeps popping up. You can not have this in your eyes and be in a well lit room. No light bulbs or flashlights, no computer screens. The chemical takes 2 hours to take effect and you should basically be keeping your eyes safe the whole time. Contacts are ok, post application.
  • KingofrandomKingofrandom March 2015
    So when can I get this and where? I would be glad to set something up.
  • glimsglims March 2015
    let me dose out what we have and then we can discuss logistics for people just tapping in.
  • chironexchironex March 2015
    depending on what's left over I *may* hop in but i dunno yet. still the overnight shipping issue
  • glimsglims March 2015
    Actually, as long as it takes less than a week, I may not have to overnight it. Since we are the proud owners of a flow spectophotometer now, I am gonna take a little bit out and let it sit on the counter and check for how much degradation actually happens.
  • chironexchironex March 2015
    that would be amazing :D
  • FrankFrank March 2015
    Can't wait to try... 

    But Q: shouldn't quantifying the effect be pretty easy as you can put it in one eye, and keep the other as a control?
  • glimsglims March 2015
    Kiiiinda. See your eyes aren't the same.
    Also, that wouldn't be quantitative, that would be subjective. Without some secondary recording device other than my brain, which may just normalize the two, it's not good data.
  • HelyxHelyx March 2015
    After seeing the fun that was had at the meetup, I'd definitely like some as well.
  • alexgreenalexgreen March 2015
    Good afternoon (I think)!

    Just got the drops and was wondering what the dosage is supposed to be. As in, how many drops does it take to get the effect? Also, what is the best storage strategy (fridge, room temperature, out of light)?
  • glimsglims March 2015
    Wow, those got to you fast!
    put them in the fridge.

    For everyone who has or will be receiving them, here is the handy reference sheet. I was going to hunt down everyone's emails, but this is easier...

    https://imgur.com/DeLApy1
  • glimsglims March 2015
    I am doing a little write up on what they are, how they work, and how to make them yourselves. Look for it soon.
  • alexgreenalexgreen March 2015
    Fantastic! Thank you!
  • glimsglims March 2015
    The write up including methods and mechanism is now available of our website. There is a PDF link for download available as well.

    http://scienceforthemasses.org/2015/03/25/a-review-on-night-enhancement-eyedrops-using-chlorin-e6/
  • ZlekratZlekrat March 2015
    This may sound really stupid, but does it work for only one eye if you put it only into it or will the chemical "traver" and make your both eyes see brighter? Because if it works for a single eye it could have bigger potencial as you could carry the pirate eyepatch over the sensitive eye and see both in the dark and in the light well.
  • glimsglims March 2015
    So the chemical won't traverse, but I'm going to have to assume that losing depth perception for a modicum of night vision acuity is probably not going to be net helpful. 
  • Nice coverage.
  • glimsglims March 2015
    Awww, we're internet famous... And on reddit no less. Those peeps are gonna find some stupid typo in the paper and tear it apart. *sigh*

    *throws cellphone into the freezer*
  • chironexchironex March 2015
    they already did^ looool
  • "These are people looking for attention. They are not contributing to science. This is not a published, peer-reviewed article. It is a document
    purporting to review a wild idea that a person decided to patent. The
    'review' describes subjecting a volunteer to a poorly supervised,
    untested, unapproved chemical treatment that could cause irreparable
    damage to vision. No reputable scientific journal would ever publish
    this study, for very good reasons."

    Dammit glims. Stop pretending to science. Also, I don't think you properly informed the patient of the risks. I mean, that guy's crazy! Of course he agreed to put drops in his eyes! I hear that dude's into weird trans-humanism stuff. Way unstable. *descending into a sar-chasm*

  • chironexchironex March 2015
    the guy who posted that comment got flammed to shit so don't even worry
  • glimsglims March 2015
    Heh, can't even see it on the sub. Evidently it got downvoted to oblivion.
  • fred4106fred4106 March 2015
    Hey, like a lot of other people here, I assumed this was a lot farther off then it ended up being. Is there any change at being able to order a bottle or two? How many uses are there per bottle?

    Thanks a bunch. Im really excited to try this out some day.

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