Scientists Found Two Metabolites That Can Influence the the Differentiation of Stem Cells
  • MandySwiftMandySwift August 2016

    Ulijn Group led by 10.0pt;font-family:"Arial","sans-serif";background:white">Rein Ulijn from New York
    has found two metabolites that can influence the differentiation direction of
    stem
    cells
    . With the finding, it’ highly possible for the development
    of single reagents that can works to make the stem cells differentiate in the
    right direction and replace the traditional boosters made of complex
    compositions, helping to save in budget.



    The present bimolecular
    cocktails working to make stem cells develop in specific directions must
    function for a reason, which is the basic foundation for the team to spot the
    exact compounds that play meaningful roles in the process.



    It has long been known that the stiffness
    and softness of a compound can influence the differentaion of stem cells before
    2011. To further probe on the theory, Ulijn, partners with a stem cell
    scientist from UK. They made fully advantages on the already found knowledge on
    this matter and began from the exploration on the stiffness and softness issue.
    According to the early finding, with soft gels, it’s likely to get neuron cells
    as a result, while in stiff gels, bone cells are more likely to be
    differentiated. The new team employed two peptides composed gels to control the
    stiffness of the gel and to decrease the variables in the process and make it
    easier to judge while add other metabolites to inspect whether they function to
    influence the developing direction of stem cells.



    In the experiment, hundreds of metabolites
    were checked, and finally
    font-family:"Arial","sans-serif";background:white"> two of them were targeted, which are lysophosphatidic acid & cholesterol sulfate. In latter stages of
    the study, reverse experiments were conducted, where these metabolites were
    applied to stem cell culture, and the designed cells were differentiated.



    The finding will be greatly helpful in
    decreasing the cost for target stem cell differentiation, especially for human primary
    cells
    and rat
    primary cells
    that are hard to get, and it can boost the development of bio
    medicals.