Genetics and Biology based mods http://forum.biohack.me/categories/gene-mods/feed.rss Mon, 23 Jan 17 10:47:57 -0800 Genetics and Biology based mods en-CA Homo sapien mutagensis http://forum.biohack.me/discussion/1909/homo-sapien-mutagensis Wed, 18 Jan 2017 14:11:13 -0800 InDubiousBattle 1909@/discussions Been a troll for a while and this is my first post

Wanted to start to share some of the stuff I have been working on in regards to human genetic design. Sorry there is an external link but it happens.
I have tons of information so it will take a while to have it internet ready so I hope people can be patient. I also want to tell a good story.

Anyways, hope this interests people here.

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PCR Heat-Block http://forum.biohack.me/discussion/1886/pcr-heat-block Tue, 27 Dec 2016 19:29:35 -0800 TorrentX 1886@/discussions
1.) Am I missing something?  Is there a place to purchase cheap heat-blocks for .2ml eppendorf tubes?  Or an alternative solution.
2.) What have others that ran into the problem done? Just ponied up for the expensive heatblock or tinkered with a homemade one til it worked?
3.) If there's no good answer to the first two questions, is this something that the community would find valuable if I worked on a solution for?
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Cellular Matrix http://forum.biohack.me/discussion/1893/cellular-matrix Tue, 03 Jan 2017 10:12:50 -0800 SourcePhoenix 1893@/discussions Nerve Enhancement? http://forum.biohack.me/discussion/1885/nerve-enhancements Tue, 27 Dec 2016 11:15:19 -0800 Cathasach 1885@/discussions
Anyone know what I'm talking about?
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A list of links on tight junctions for cell adhesion(WIKIPEDIA) http://forum.biohack.me/discussion/1897/a-list-of-links-on-tight-junctions-for-cell-adhesionwikipedia Thu, 05 Jan 2017 08:17:38 -0800 Zwytechhacker 1897@/discussions https://en.wikipedia.org/wiki/TJP3
https://en.wikipedia.org/wiki/Tight_junction_protein_1
https://en.wikipedia.org/wiki/F11_receptor
https://en.wikipedia.org/wiki/CASK
https://en.wikipedia.org/wiki/TBR1
https://en.wikipedia.org/wiki/GJA3
https://en.wikipedia.org/wiki/GJA8
https://en.wikipedia.org/wiki/GJA1
https://en.wikipedia.org/wiki/KIRREL
https://en.wikipedia.org/wiki/MLLT4
https://en.wikipedia.org/wiki/Tight_junction_protein_2
https://en.wikipedia.org/wiki/EPB41
https://en.wikipedia.org/wiki/Occludin
http://www.zonapse.net/tight_junction/
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Decellularizing tissue http://forum.biohack.me/discussion/1396/decellularizing-tissue- Sun, 13 Mar 2016 21:29:03 -0700 chironex 1396@/discussions
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Genetic Modification of Yeast and Bacteria to work for us http://forum.biohack.me/discussion/1882/genetic-modification-of-yeast-and-bacteria-to-work-for-us Sat, 24 Dec 2016 09:35:22 -0800 RealityWizard 1882@/discussions Ce6 http://forum.biohack.me/discussion/745/ce6 Tue, 25 Nov 2014 12:33:48 -0800 glims 745@/discussions
We should have them ready soon. Basically, I'm just making sure that I can get the amounts right and not scorch your eyes. The papers and patents we have access to are very specific in some regards and very vague in others. As @Cassox mentioned, this chemical is used in lazering cancer cells (my paraphrase) so obviously, exploding your eye bits by tiny molecular focuses of daylight would... suck.

Progress is being made. It's just me reading and then mixing things together and measuring light bits.

For those who are ready to chip in and talk about that patent, their amounts are theoretical and were used just to lock the patent down. Got get this right so nobody gets hurt. Eyes are important

Anyone have any questions, let me know.
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Removing Toenails http://forum.biohack.me/discussion/1711/removing-toenails Thu, 01 Sep 2016 18:04:17 -0700 eggit 1711@/discussions dna & coding.. http://forum.biohack.me/discussion/1832/dna-coding.. Tue, 22 Nov 2016 06:12:45 -0800 Wyldstorm 1832@/discussions And one thing i cant really find good data on is level 2+ coding.. 

So, anyone know?
How many levels of coding are there in the dna?
How the hell do i compute the consequences?
Is there a good refutation?
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New Crispr News!! http://forum.biohack.me/discussion/1824/new-crispr-news Sat, 19 Nov 2016 14:54:00 -0800 _Larry_ 1824@/discussions China just made some rather large advances with real life uses for Crispr!
https://www.wired.com/2016/11/china-used-crispr-fight-cancer-real-live-human/

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Has anyone shot yourself with Capsaicin? http://forum.biohack.me/discussion/1646/has-anyone-shot-yourself-with-capsaicins Fri, 22 Jul 2016 11:27:48 -0700 opi 1646@/discussions
I'm interested in its effect on systemic pain nerve degeneration to become a pain-free-forever cyborg, but I also heard it can give you a sense of "high". So yeah, for recreational or whatever other purposes, I'd like to hear your adventures with Capsaicin! :)

Some stuff I think I know about Capsaicin:
- desensitize TRPV1 nerves by destroying them
- better to inject intrathetically to minimize systemic side-effects while killing main spinal pain nerves
- systemic temporary side effects include bradycardia, apnea, body temp decrease

Since I can't inject in my own spine, the most practical way seems to be into a vein.
My hypothesis is that if I inject very little each time, it will affect the heart and respiratory functions minimally, and some Capsaicin will end up in the CSF, killing a few pain nerves there, and if I repeat this many times, I can eventually get rid of most pain nerves.
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Telomerase Reverse Transcriptase Enzyme Injections for Improving Longetivity http://forum.biohack.me/discussion/1720/telomerase-reverse-transcriptase-enzyme-injections-for-improving-longetivity Tue, 06 Sep 2016 05:14:52 -0700 Finn333 1720@/discussions our kids out smart us... http://forum.biohack.me/discussion/1765/our-kids-out-smart-us... Fri, 07 Oct 2016 16:58:30 -0700 Meanderpaul 1765@/discussions
We ended up take an older iPad that has basically been put away and wiped then added baby apps to it (simple games and such) she seems to target one game and one other app which is basically a kids version of youtube. she has mastered the game and will scroll through the youtube app looking for the video she wants.

This too me makes me think about memory or knowledge being passed on to our kids, not through teaching but genetically. I know she likely learned how to navigate by watching us and by trial and error but it just seems too fluid and quick. 

Is it possible that a baby actually has this innate knowledge from what their parents have done or even their ancestors? why wouldn't, if its possible, they be able to hold onto that knowledge from further back? we see it in animals who instinctively know how to survive and what danger is from a young age.

If I'm right could baby speak really be something more then just gibberish? There is plenty of people ( and videos) of sibling babies having conversations with each other. could it really be a combination or remnants of previous languages that existed before?

I know this is a pretty out there thought (even for me). Thoughts?
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Hive Body Modification http://forum.biohack.me/discussion/1757/hive-body-modification Mon, 03 Oct 2016 11:10:18 -0700 kscottb 1757@/discussions personally i would think creating a sub-dermal/trans-dermal hive cavity on a shoulder would by the best way to do this, I was wondering also if one was capable of creating this "hive-space" if one could modify there body to create a hormone that attracts a said insect to the body, calling it their home and if possible a hormone of danger(Similar to a Queen releasing a hormone that the hive is under attack)  or if not produced from the body organically possible artificially? I think it would be more of a interesting project in term of symbiosis and modification of the body required. im not so much concerned of they "why would you do that", but rather the if its possible, how would it be done?]]> Hypothetical Data Storage in B Cells http://forum.biohack.me/discussion/1755/hypothetical-data-storage-in-b-cells Sun, 02 Oct 2016 08:14:31 -0700 Jupiter 1755@/discussions
I was thinking about how one could tell the immune system to ignore a certain material or other organism (which goes back to my idea to implant an independent organism to serve one of many functions). In thinking about all this, I thought about how the immune system in most mammals had a sort of "memory" that identifies previously encountered diseases. I thought, "what if we could 'identify' a custom made disease, thereby remembering the disease structure and using that method to store data".

Anyone have any thoughts on this? I'll admit that the whole process by which B Cells go about remembering diseases is somewhat complicated and I don't understand it very well. I did think that it's a wild idea that I doubted anyone here had come up with before, so I bought I'd bring it up for discussion. I'all point out that I tend to feel that inorganic technology is easier to scientifically test and experiment with and as a result easier to develop and more reliable to use, so if given the choice, I'd rather have some sort of implanted electronic mass storage device, not my immune system idea, but... discussing it anyways. ]]>
Night vision? http://forum.biohack.me/discussion/1424/night-visions Tue, 05 Apr 2016 21:27:09 -0700 Xerokg 1424@/discussions I've read the multiple articles on the injection of Ce6 into the conjunctival sac to give the effect.. however, have you seen the eyes afterwards? That's something that might make people shy away from biohacking, or just scare children. So I guess my question is more along the lines of "could we grant nightvision with only cat-like reflective pupils?" Thoughts?
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Becoming Insensitivite to Pain? http://forum.biohack.me/discussion/1633/becoming-insensitivite-to-pains Thu, 14 Jul 2016 06:27:38 -0700 opi 1633@/discussions
...Like the people who have CIP (Congenital Insensitivity to Pain) whose sensations are all intact except pain.
https://en.wikipedia.org/wiki/Congenital_insensitivity_to_pain

Let's share ideas. I want to know different ways you can become this (or close), either long-term or permanently :D
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genetic modification ethical and moral issues http://forum.biohack.me/discussion/1679/genetic-modification-ethical-and-moral-issues Wed, 17 Aug 2016 17:49:41 -0700 Jordygordy 1679@/discussions obviously no one is going to be modifying their genes in their garage today or anytime in the near future (and if you are, please message me because i want in on that action). So as a community I would like us to stay a bit ahead of the game and open up a discussion now on what we think is and isn't ok and maybe consider forming some sort of community guidelines; obviously we won't be able to enforce anything, but recommending and discouraging possibly dangerous modifications should be considered. 

For instance, I suggest we don't edit any genes that can be passed down to future generations, so that means nothing in the testicles/ovaries and nothing with eggs/sperm. 

The complications of this are unknown and risking the lives of our children and future generations isn't worth the risk especially if enough people screw up their genes, they could ultimately alter the evolution of humanity.

Another issue, making sure we don't accidentally create anything lethal that could cause some sort of disease or something.

With that being said, I would say any other genetic modifications are ok. Everyone here is ok with stepping into the unknown and risking danger and harming their bodies for the sake science and be so go at your own risk. 

so lets open this up and add in what else we should try to discourage or what we should encourage /  what direction we should go in. 
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Invasive replacement/deletion genes http://forum.biohack.me/discussion/1674/invasive-replacementdeletion-genes- Mon, 15 Aug 2016 00:58:57 -0700 Sebastian 1674@/discussions
could the bodies natural protection be turned against certian genes to forcibly delete them or even replace them. This could make manual gene manipulation something that could be done with a syringe containing an invasive gene modified to recognize gene(n) as a threat.

*DISCLAIMER* Icould be 100% wrong and crazy
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Is there such thing as a commercial, human Crispr gene knockout kit? http://forum.biohack.me/discussion/1660/is-there-such-thing-as-a-commercial-human-crispr-gene-knockout-kits- Wed, 03 Aug 2016 00:21:48 -0700 Arkcon10 1660@/discussions
(also i understand that Human genetic editing is not exactly a "common science" in america, so i highly doubt there will be some form or any form of genomic kit for doing things such as this but i'd thought i'd ask anyways) 

(TLDR: im asking if there's such thing as a human cell editing kit and if not, if there's a method of creating genetic code strands to be implemented into a pre existing kit) 
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New biotech DNA company http://forum.biohack.me/discussion/984/new-biotech-dna-company Fri, 10 Jul 2015 11:20:19 -0700 Instant_Chemistry 984@/discussions Hi Everyone,

This is my first post to the community.  

My wife and I started a biotech company in 2014 that uses genetic and
psychological testing for the dating industry. We have expertise in genetics
and neuroscience and a passion for making DNA testing accessible to everyone.
We've recently launched a new product called Gemetrics which will allow you to
explore three neurogenetic variants that have been strongly linked to
behavioral traits (for under $50).

My longer term goal is to develop an inexpensive a la carte platform
that will allow you to anonymously test and compare your genetic traits to
everyone else on the database and discover what makes you unique. When that
platform is ready, you'll be able to find your genetic uniqueness and then
exploit it as much as possible.

I'm coming to you to explore which other ideas or tests you want to see
created?  We've got the lab and the people to do it!











Would love to hear from you...

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Power generation via synthetic biology? http://forum.biohack.me/discussion/1511/power-generation-via-synthetic-biologys Tue, 17 May 2016 15:54:14 -0700 LeslieJM 1511@/discussions ]]> ACTV-1 http://forum.biohack.me/discussion/1630/actv-1 Mon, 11 Jul 2016 06:15:06 -0700 Wyldstorm 1630@/discussions
Has anyone taken ACTV-1 seriously and tested themselves?
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How about the market of magnetic beads? http://forum.biohack.me/discussion/1282/how-about-the-market-of-magnetic-beadss Thu, 14 Jan 2016 23:44:58 -0800 venus666 1282@/discussions Hi , I am working with lifescience and my company want to develop a new products---octyl c8 magnetic beads
. I have known the biotech market is of much potential. But I am not very familiar with the new product. How about the market?

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Some how I feel this has come up http://forum.biohack.me/discussion/1576/some-how-i-feel-this-has-come-up Mon, 06 Jun 2016 18:27:56 -0700 Meanderpaul 1576@/discussions
I know the gene is from a jellyfish and injected into the fish egg. Then the offspring of the injected fish has the gene to glow and will glow.

Now the obvious question. Can this be adapted to a mammal such as chicken or other animal. I'm clearly thinking human as well but that time line to see it would take AWHILE.]]>
Mitochondria 2.0? http://forum.biohack.me/discussion/1086/mitochondria-2.0s Wed, 23 Sep 2015 17:56:01 -0700 chironex 1086@/discussions
Thoughts?
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That darn bbb.... http://forum.biohack.me/discussion/1561/that-darn-bbb.... Fri, 03 Jun 2016 07:50:01 -0700 Wyldstorm 1561@/discussions http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149178/
But im kinda unconvinced.. 

Will it really pass the BBB?
How does one do a genetic change in an adult subject?
And how difficult is it to make the change thoughout the body?
And with a dna change, how far can one go before changed cells are attacked by the body's own defences?
And.. Those darn epigenetics, is there some way to change/block those?

Im kinda curious, and can only get so far with mindless googling and the occasional paper.. 
Can anyone direct me to a good source?
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Crispr procedure http://forum.biohack.me/discussion/1343/crispr-procedure Sun, 14 Feb 2016 22:31:36 -0800 Arkcon10 1343@/discussions If someone could answer my questions i would extremely appreciate it ]]> Oxycyte carries oxygen 50 times as effectively as our own blood http://forum.biohack.me/discussion/1514/oxycyte-carries-oxygen-50-times-as-effectively-as-our-own-blood Wed, 18 May 2016 08:35:48 -0700 sirus20x6 1514@/discussions https://en.wikipedia.org/wiki/Oxycyte

Wondering what this could do for our body's capacity for exercise, work, or to supplement function that is lost for aging or disease. Again like most of my posts if anyone knows where to buy it (or make I guess) that would be also great.
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