Genetics and Biology based mods http://forum.biohack.me/categories/gene-mods/feed.rss Sat, 29 Apr 17 20:19:32 -0700 Genetics and Biology based mods en-CA Biohackers & FDA - Call to Action http://forum.biohack.me/discussion/1922/biohackers-fda-call-to-action- Wed, 01 Feb 2017 21:51:56 -0800 cyberlass 1922@/discussions At Bodyhacking Con there was discussion about the Josiah Zayner & David Ishee chat on Biohackers and the FDA. In particular the biohacking - DIY Bio community is pushing back against the FDA proposed regulation "Intentionally Altered Genomic DNA in Animals".  This is a starting point for regulation into our community and we should be working together to obtain the best outcome.

Please watch the video: http://youtu.be/4IrTUvvcLj4 and take action:

If you aren't sure what to write, you can check out the 200+ public comments for ideas https://www.regulations.gov/docketBrowser?rpp=50&so=DESC&sb=postedDate&po=0&dct=PS&D=FDA-2008-D-0394

Other things we can do:
  • Raise awareness and support through media 
  • Write a blog post about the conflict the DIY Bio part of our community is experiencing
  • Make/go on a podcast about this issue
  • Interview someone in the DIY Bio community and publish it 
  • Social media posts (I know, I know but it is a factor)
  • Reach out to your DIY Bio contacts and see what they need, let the rest of us know if there is more we can do to help

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Modify your own genetics to have a high proportion of fast twitch muscle? http://forum.biohack.me/discussion/1992/modify-your-own-genetics-to-have-a-high-proportion-of-fast-twitch-muscles Mon, 03 Apr 2017 02:17:44 -0700 tryingtomakeit 1992@/discussions "These are ACE and ACTN3 genes. Independent research has confirmed the connection between the genotype of ACE (angiotensin converting enzyme) and athletic performance. ACE gene has two gene variants: ACE I and ACE D. Gene variant ACE I raises ability in endurance sports or, in other words, the bearer of this gene has averagely higher endurance. Researches have indicated a more frequent occurrence of this gene combination on many top sportsmen of several endurance sports (running, skiing, rowing, triathlon etc). The bearers of gene variant ACE D have, on the contrary, averagely better abilities of strength and speed." 
 I need ACTN3 and ACE D but if i could change them would they affect my fiber type composition as an adult? are there any other know genes to affect this?

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Augmenting the Sense of Smell http://forum.biohack.me/discussion/1975/augmenting-the-sense-of-smell Tue, 14 Mar 2017 00:08:59 -0700 Maxwell 1975@/discussions Nerve Enhancement? http://forum.biohack.me/discussion/1885/nerve-enhancements Tue, 27 Dec 2016 11:15:19 -0800 Cathasach 1885@/discussions
Anyone know what I'm talking about?
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Learning microbiology the fun way http://forum.biohack.me/discussion/1995/learning-microbiology-the-fun-way Mon, 03 Apr 2017 09:58:17 -0700 chironex 1995@/discussions I believe the best way to learn biology, and microbiology in particular, is to experience it. By actually working with the organisms you get so much more understanding than by just reading about them. So to serve as an introduction to microbiology, I made this little tutorial on how to make wine and mead. Yeast is just so easy to cultivate, so it serves as a great teaching tool to get people used to working with organisms like this. I'll be building on it in the future and looking at more advanced skills like using a bioreactor and culturing more difficult organisms. 

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Prevent scurvy, increase regeneration of skin and increase overall bodily health through goats http://forum.biohack.me/discussion/1988/prevent-scurvy-increase-regeneration-of-skin-and-increase-overall-bodily-health-through-goats Wed, 29 Mar 2017 12:59:28 -0700 Mael 1988@/discussions I recently learned that goats have a gene in their liver that enables them to produce vitamin c independantly and im thinking that perhaps using that gene (which is shown to work in animals) in either bacteria to easily produce vitamin c or, using crispr to edit human cells to produce it might be a good test to run to see if by providing a source of vitamin c creation in the body, one may have the ability to heal collegen and other tissue through there body itself
P.s. posting via phone sorry for poor grammar and inconsitentcy
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Radiation Resistant Blood (think The 100) http://forum.biohack.me/discussion/1974/radiation-resistant-blood-think-the-100 Fri, 10 Mar 2017 12:16:57 -0800 Finn333 1974@/discussions
Firstly, the radiation resistance. I've been reading up on a study that was working on a new way to treat radiation sickness. In the study, they took a sample of e. coli and subjected it to radiation. After 99 percent of the sample died, they let the population grow back. After twenty iterations of rinse and repeat, the team created a sample of e. coli that could reverse the effects of radiation. Then, you take a sample of your blood. You then bind the e. coli to the sample and inject it into yourself. Now, you have a bigger radiation tolerance than most people.
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Stimulating Muscle Growth http://forum.biohack.me/discussion/1984/stimulating-muscle-growth Thu, 23 Mar 2017 19:46:38 -0700 Liamwils404 1984@/discussions https://www.sciencedaily.com/releases/2016/02/160218132300.htm]]> TUES FEB 21 IS THE NEW WEBSITE GO-LIVE [CROSS-CATEGORY POST] http://forum.biohack.me/discussion/1945/tues-feb-21-is-the-new-website-go-live-cross-category-post Fri, 17 Feb 2017 13:24:54 -0800 cyberlass 1945@/discussions http://forum.biohack.me/discussion/1942/updated-tues-feb-21-is-the-new-website-go-live

Note: Your user account will be on new system, BUT you will have to do a password reset.
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Homo sapien mutagensis http://forum.biohack.me/discussion/1909/homo-sapien-mutagensis Wed, 18 Jan 2017 14:11:13 -0800 InDubiousBattle 1909@/discussions Been a troll for a while and this is my first post

Wanted to start to share some of the stuff I have been working on in regards to human genetic design. Sorry there is an external link but it happens.
I have tons of information so it will take a while to have it internet ready so I hope people can be patient. I also want to tell a good story.

Anyways, hope this interests people here.

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Hive Body Modification http://forum.biohack.me/discussion/1757/hive-body-modification Mon, 03 Oct 2016 11:10:18 -0700 kscottb 1757@/discussions personally i would think creating a sub-dermal/trans-dermal hive cavity on a shoulder would by the best way to do this, I was wondering also if one was capable of creating this "hive-space" if one could modify there body to create a hormone that attracts a said insect to the body, calling it their home and if possible a hormone of danger(Similar to a Queen releasing a hormone that the hive is under attack)  or if not produced from the body organically possible artificially? I think it would be more of a interesting project in term of symbiosis and modification of the body required. im not so much concerned of they "why would you do that", but rather the if its possible, how would it be done?]]> The mysterious 98%: Scientists look to shine light on the 'dark genome' http://forum.biohack.me/discussion/1926/the-mysterious-98-scientists-look-to-shine-light-on-the-dark-genome Sat, 04 Feb 2017 05:38:15 -0800 SourcePhoenix 1926@/discussions

I think it's mainly a very complex translation process for 1) useful functions, 2) frameworks for patterns, geometry, compression, etc. 3) shared abstract memories shared at the species level or a sub scope of some sort 4) check systems 5) a merging system that's specifically adapted for the potential of mutations and maybe tries to harness "mutational noise" 6) ... I could think about this more but I got work to do.

What do you all think?

I wonder if A.I. systems & genetic algorithms incorporate this today.
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Real & theorical symbiosis usage in bio/gene modifcation http://forum.biohack.me/discussion/1931/real-theorical-symbiosis-usage-in-biogene-modifcation Tue, 07 Feb 2017 17:01:04 -0800 SymbiosisIsKey 1931@/discussions media take off in many ways since the 1940s sci-fi boom. Whether it be the idea of alien creatures
from other worlds bonding with people(The Venom family of Symboties, Guyver Units and so on). Or plants, parasites and biomedical made
creatures hybridized with humans to something more(Metal Gear's The End, Parasyte). But we also have rather real
possibilities for symbiosis, as shown by microbiota, already available in the real world. For those unaware we
have an ecosystem of things living within or on us that make our life generally
easier and we are keeping them fed, sheltered and safe for lack of a better analogy. As my name and the title suggest, I believe deep down bio and gene modding can be improved if we push elements of symbiosis further, we'd just need to bio and gene mod other creatures as well as ourselves. Imagine if we could improve the proteins a medical leech(Hirudo Medicinalis) produces to increase better blood flow through out more of the body while still feeding it. Or taking any of the many elements of helminethic therapy (using what is normally considered parasitic creatures as helpers to tackle issues) and modifying their genetics to improve other things within us; namely to the point they become mutually beneficial to us and no longer a hazard.

Have you had thoughts of this? Do you know anyone actually trying to do this?  Ever catch a glimpse of someone possibly on to something and want to share? I've read a few topics on here that dip into on this subject and wanted to unify it with one topic and get people who have had it on their minds.
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PCR Heat-Block http://forum.biohack.me/discussion/1886/pcr-heat-block Tue, 27 Dec 2016 19:29:35 -0800 TorrentX 1886@/discussions
1.) Am I missing something?  Is there a place to purchase cheap heat-blocks for .2ml eppendorf tubes?  Or an alternative solution.
2.) What have others that ran into the problem done? Just ponied up for the expensive heatblock or tinkered with a homemade one til it worked?
3.) If there's no good answer to the first two questions, is this something that the community would find valuable if I worked on a solution for?
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Cellular Matrix http://forum.biohack.me/discussion/1893/cellular-matrix Tue, 03 Jan 2017 10:12:50 -0800 SourcePhoenix 1893@/discussions A list of links on tight junctions for cell adhesion(WIKIPEDIA) http://forum.biohack.me/discussion/1897/a-list-of-links-on-tight-junctions-for-cell-adhesionwikipedia Thu, 05 Jan 2017 08:17:38 -0800 Zwytechhacker 1897@/discussions https://en.wikipedia.org/wiki/TJP3
https://en.wikipedia.org/wiki/Tight_junction_protein_1
https://en.wikipedia.org/wiki/F11_receptor
https://en.wikipedia.org/wiki/CASK
https://en.wikipedia.org/wiki/TBR1
https://en.wikipedia.org/wiki/GJA3
https://en.wikipedia.org/wiki/GJA8
https://en.wikipedia.org/wiki/GJA1
https://en.wikipedia.org/wiki/KIRREL
https://en.wikipedia.org/wiki/MLLT4
https://en.wikipedia.org/wiki/Tight_junction_protein_2
https://en.wikipedia.org/wiki/EPB41
https://en.wikipedia.org/wiki/Occludin
http://www.zonapse.net/tight_junction/
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Decellularizing tissue http://forum.biohack.me/discussion/1396/decellularizing-tissue- Sun, 13 Mar 2016 21:29:03 -0700 chironex 1396@/discussions
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Genetic Modification of Yeast and Bacteria to work for us http://forum.biohack.me/discussion/1882/genetic-modification-of-yeast-and-bacteria-to-work-for-us Sat, 24 Dec 2016 09:35:22 -0800 RealityWizard 1882@/discussions Ce6 http://forum.biohack.me/discussion/745/ce6 Tue, 25 Nov 2014 12:33:48 -0800 glims 745@/discussions
We should have them ready soon. Basically, I'm just making sure that I can get the amounts right and not scorch your eyes. The papers and patents we have access to are very specific in some regards and very vague in others. As @Cassox mentioned, this chemical is used in lazering cancer cells (my paraphrase) so obviously, exploding your eye bits by tiny molecular focuses of daylight would... suck.

Progress is being made. It's just me reading and then mixing things together and measuring light bits.

For those who are ready to chip in and talk about that patent, their amounts are theoretical and were used just to lock the patent down. Got get this right so nobody gets hurt. Eyes are important

Anyone have any questions, let me know.
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Removing Toenails http://forum.biohack.me/discussion/1711/removing-toenails Thu, 01 Sep 2016 18:04:17 -0700 eggit 1711@/discussions dna & coding.. http://forum.biohack.me/discussion/1832/dna-coding.. Tue, 22 Nov 2016 06:12:45 -0800 Wyldstorm 1832@/discussions And one thing i cant really find good data on is level 2+ coding.. 

So, anyone know?
How many levels of coding are there in the dna?
How the hell do i compute the consequences?
Is there a good refutation?
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New Crispr News!! http://forum.biohack.me/discussion/1824/new-crispr-news Sat, 19 Nov 2016 14:54:00 -0800 _Larry_ 1824@/discussions China just made some rather large advances with real life uses for Crispr!
https://www.wired.com/2016/11/china-used-crispr-fight-cancer-real-live-human/

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Has anyone shot yourself with Capsaicin? http://forum.biohack.me/discussion/1646/has-anyone-shot-yourself-with-capsaicins Fri, 22 Jul 2016 11:27:48 -0700 opi 1646@/discussions
I'm interested in its effect on systemic pain nerve degeneration to become a pain-free-forever cyborg, but I also heard it can give you a sense of "high". So yeah, for recreational or whatever other purposes, I'd like to hear your adventures with Capsaicin! :)

Some stuff I think I know about Capsaicin:
- desensitize TRPV1 nerves by destroying them
- better to inject intrathetically to minimize systemic side-effects while killing main spinal pain nerves
- systemic temporary side effects include bradycardia, apnea, body temp decrease

Since I can't inject in my own spine, the most practical way seems to be into a vein.
My hypothesis is that if I inject very little each time, it will affect the heart and respiratory functions minimally, and some Capsaicin will end up in the CSF, killing a few pain nerves there, and if I repeat this many times, I can eventually get rid of most pain nerves.
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Telomerase Reverse Transcriptase Enzyme Injections for Improving Longetivity http://forum.biohack.me/discussion/1720/telomerase-reverse-transcriptase-enzyme-injections-for-improving-longetivity Tue, 06 Sep 2016 05:14:52 -0700 Finn333 1720@/discussions our kids out smart us... http://forum.biohack.me/discussion/1765/our-kids-out-smart-us... Fri, 07 Oct 2016 16:58:30 -0700 Meanderpaul 1765@/discussions
We ended up take an older iPad that has basically been put away and wiped then added baby apps to it (simple games and such) she seems to target one game and one other app which is basically a kids version of youtube. she has mastered the game and will scroll through the youtube app looking for the video she wants.

This too me makes me think about memory or knowledge being passed on to our kids, not through teaching but genetically. I know she likely learned how to navigate by watching us and by trial and error but it just seems too fluid and quick. 

Is it possible that a baby actually has this innate knowledge from what their parents have done or even their ancestors? why wouldn't, if its possible, they be able to hold onto that knowledge from further back? we see it in animals who instinctively know how to survive and what danger is from a young age.

If I'm right could baby speak really be something more then just gibberish? There is plenty of people ( and videos) of sibling babies having conversations with each other. could it really be a combination or remnants of previous languages that existed before?

I know this is a pretty out there thought (even for me). Thoughts?
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Hypothetical Data Storage in B Cells http://forum.biohack.me/discussion/1755/hypothetical-data-storage-in-b-cells Sun, 02 Oct 2016 08:14:31 -0700 Jupiter 1755@/discussions
I was thinking about how one could tell the immune system to ignore a certain material or other organism (which goes back to my idea to implant an independent organism to serve one of many functions). In thinking about all this, I thought about how the immune system in most mammals had a sort of "memory" that identifies previously encountered diseases. I thought, "what if we could 'identify' a custom made disease, thereby remembering the disease structure and using that method to store data".

Anyone have any thoughts on this? I'll admit that the whole process by which B Cells go about remembering diseases is somewhat complicated and I don't understand it very well. I did think that it's a wild idea that I doubted anyone here had come up with before, so I bought I'd bring it up for discussion. I'all point out that I tend to feel that inorganic technology is easier to scientifically test and experiment with and as a result easier to develop and more reliable to use, so if given the choice, I'd rather have some sort of implanted electronic mass storage device, not my immune system idea, but... discussing it anyways. ]]>
Night vision? http://forum.biohack.me/discussion/1424/night-visions Tue, 05 Apr 2016 21:27:09 -0700 Xerokg 1424@/discussions I've read the multiple articles on the injection of Ce6 into the conjunctival sac to give the effect.. however, have you seen the eyes afterwards? That's something that might make people shy away from biohacking, or just scare children. So I guess my question is more along the lines of "could we grant nightvision with only cat-like reflective pupils?" Thoughts?
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Becoming Insensitivite to Pain? http://forum.biohack.me/discussion/1633/becoming-insensitivite-to-pains Thu, 14 Jul 2016 06:27:38 -0700 opi 1633@/discussions
...Like the people who have CIP (Congenital Insensitivity to Pain) whose sensations are all intact except pain.
https://en.wikipedia.org/wiki/Congenital_insensitivity_to_pain

Let's share ideas. I want to know different ways you can become this (or close), either long-term or permanently :D
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genetic modification ethical and moral issues http://forum.biohack.me/discussion/1679/genetic-modification-ethical-and-moral-issues Wed, 17 Aug 2016 17:49:41 -0700 Jordygordy 1679@/discussions obviously no one is going to be modifying their genes in their garage today or anytime in the near future (and if you are, please message me because i want in on that action). So as a community I would like us to stay a bit ahead of the game and open up a discussion now on what we think is and isn't ok and maybe consider forming some sort of community guidelines; obviously we won't be able to enforce anything, but recommending and discouraging possibly dangerous modifications should be considered. 

For instance, I suggest we don't edit any genes that can be passed down to future generations, so that means nothing in the testicles/ovaries and nothing with eggs/sperm. 

The complications of this are unknown and risking the lives of our children and future generations isn't worth the risk especially if enough people screw up their genes, they could ultimately alter the evolution of humanity.

Another issue, making sure we don't accidentally create anything lethal that could cause some sort of disease or something.

With that being said, I would say any other genetic modifications are ok. Everyone here is ok with stepping into the unknown and risking danger and harming their bodies for the sake science and be so go at your own risk. 

so lets open this up and add in what else we should try to discourage or what we should encourage /  what direction we should go in. 
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Invasive replacement/deletion genes http://forum.biohack.me/discussion/1674/invasive-replacementdeletion-genes- Mon, 15 Aug 2016 00:58:57 -0700 Sebastian 1674@/discussions
could the bodies natural protection be turned against certian genes to forcibly delete them or even replace them. This could make manual gene manipulation something that could be done with a syringe containing an invasive gene modified to recognize gene(n) as a threat.

*DISCLAIMER* Icould be 100% wrong and crazy
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